The Green Chemistry Approach Used For Quick Synthesis

In this study, the green chemistry approach was used for quick synthesis (within 30 seconds) of gold nanoparticles (AuNPs) by using the fruit extract of Limonia acidissima L. The study focused on the formation of Limonia acidissima L stabilized AuNPs without using any catalytic agent. The AuNPs was confirmed by observation of the surface plasmon resonance (SPR) band at 537 nm. On the surface of these capped AuNPs, epirubicin (EPI) was conjugated along with activated folic acid (FA) for targeted drug delivery. The EPI-FA-AuNPs complex was characterized using FT-IR and UV-visible spectrophotometer and the AuNPs were characterized by HR-TEM, particle size analyzer and zeta potential measurement. In-vitro stability revealed that the AuNPs were†¦show more content†¦[1].To overcome this problem we have established a method to synthesize gold nanoparticles (AuNPs) functionalized with folic acid (FA) for targeted delivery of epirubicin (EPI), an anthracycline chemotherapy agent. [2] . EPI has been clinically used to treat various types of cancer, such as breast cancer, lymphomas, sarcomas in soft-tissue, pancreatic cancer, gastric cancer, small-cell lung cancer and acute leukemia. EPI shows less hematologic or myocardial toxicity at comparable doses [3]. AuNPs are identified as favorable candidates for drug delivery applications due to their unique dimensions, tunable surface functionalities, nontoxicity and controlled drug release capability [4]. Green chemistry-based eco-friendly methods are predominantly used for the synthesis of AuNPs instead of chemical synthesis [5]. Plant extracts are used as reducing and stabilizing agents to synthesise the nanoparticles. Plant extracts contain different concentrations and combinations of organic reducing agents, which